Vilazodone (Viibryd) is an antidepressant medication used to treat depression. Like other antidepressants, it is not a controlled substance, and its use is not likely to result in abuse or addiction. It is important to use vilazodone exactly as prescribed, as adverse effects can occur, and cessation of the medication can result in withdrawal symptoms.
- Vilazodone is an antidepressant medication.
- Vilazodone is not a controlled substance.
- Vilazodone abuse and addiction are rare, although dependence can occur with prolonged use.
-Controlled-Substance-Status.jpg?v=1770196573)
Is vilazodone (Viibryd) a controlled substance?
No, vilazodone (Viibryd) is not a controlled substance. Vilazodone is an antidepressant medication approved to treat major depressive disorder (MDD) in adults and used off-label to treat anxiety disorders. Vilazodone is a unique antidepressant, closely related to selective serotonin reuptake inhibitors (SSRIs), but with an additional action. It is sometimes termed a serotonin partial agonist and reuptake inhibitor (SPARI). [1]
Vilazodone is not a controlled substance, as it is not deemed to have abuse and addiction potential. Controlled substances are classed within five schedule categories depending on the potential for abuse and harm, and whether they have approved medical uses. Vilazodone is available on prescription only and cannot be bought over the counter.
Does vilazodone have abuse or dependence potential?
Vilazodone is not likely to cause abuse or addiction. Although antidepressants, such as vilazodone, work by impacting mood, they do not tend to cause a feeling of euphoria or ‘high’ that is commonly associated with abuse and addiction. [2][3] However, it is important to note that some individuals, particularly those with a history of substance abuse, might misuse antidepressants for their effects, alone or alongside other substances. [3]
Vilazodone may lead to the development of physical dependence, particularly with long-term use. Vilazodone impacts neurotransmitter activity, and over time, the body adapts to the medication's effects, so continued use is required to maintain function. Once the medication is stopped, especially if it is stopped abruptly, there is a sudden change in neurotransmitter levels, which results in the physical and psychological symptoms of withdrawal, including: [4]
- Headaches
- Fatigue
- Confusion
- Dizziness
- Irritability
- Agitation
- Trouble sleeping
- Anxiety
- Tingling in the hands or feet
- Changes in mood
- Suicidal ideation
- Sweating
- Electric shock-like sensations in the brain, known as brain zaps
Because of this, it is recommended when stopping vilazodone or other antidepressants, to make gradual dose reductions.
Why some people worry about vilazodone being addictive
Vilazodone, like many other antidepressants, can cause discontinuation syndrome, or withdrawal symptoms, when the medication is stopped. This can cause unpleasant or distressing symptoms.
Some people may confuse the onset of withdrawal symptoms with the development of addiction. However, although these symptoms are an indication that the individual has developed some physical dependence upon the medication, it does not mean that they have developed an addiction.
Dependence and addiction differ; dependence is related to the body becoming accustomed to the effects of the drug, which causes these physical and psychological symptoms when it is stopped. Addiction, however, is related to changes in mood and behavior that result in negative consequences, urges, and cravings for drug use, and uncontrollable use.
How is Viibryd different from other SSRIs?
Viibryd is sometimes classed as an SSRI, although it differs in certain aspects. SSRIs block the reuptake of serotonin, thereby increasing serotonin levels in the brain. Vilazodone also activates this mechanism and acts as a partial agonist at serotonin receptors. This additional action is thought to enhance serotonin activity and potentially influence side effects. [1][5]
For example, compared to other SSRIs, vilazodone is seen to have a faster onset of effects, fewer sexual and weight-related side effects, and potentially greater antidepressant and anxiolytic efficacy. [1][5]
Vilazodone can be used as a first-line antidepressant treatment and may be particularly useful for individuals who experience sexual dysfunction or weight gain, intolerance, or ineffectiveness with other SSRIs. [1]
-guide-detail.jpg?v=1722503452)
-guide-detail.jpg?v=1746009761)
_-Uses,-Effects,-&-Safety-guide-detail.jpg?v=1761578103)