Zoloft is one of the most popular antidepressants in the United States. It is the brand name for sertraline, a drug that alleviates the symptoms of various mental health disorders.
- Ceasing Zoloft use abruptly can cause SSRI Discontinuation Syndrome, leading to rebound anxiety and depression
- SSRI antidepressants like Zoloft help those who produce lower than normal levels of serotonin, which can lead to conditions such as major depressive disorder and post-traumatic stress disorder
- Most doctors will advise patients using drugs such as Zoloft to taper off of the substance by reducing the dosage or switching to less potent SSRIs
Understanding Zoloft
Zoloft falls under the group of antidepressants classed as selective serotonin reuptake inhibitor(s) (SSRIs) which are used to treat multiple mental health disorders by rebalancing the levels of serotonin in the brain. People with low levels of serotonin often suffer from mental disorders as it is the neurotransmitter that regulates emotion. Some common disorders treated by Zoloft include:
- Depressive disorder
- Obsessive-compulsive disorder (OCD)
- Panic and anxiety disorders
- Social anxiety disorder
- Post-traumatic stress disorder (PTSD)
- Premenstrual dysphoric disorder
It is also sometimes used as a treatment for eating disorders such as food addiction and for those suffering from insomnia. SSRIs like Zoloft work by blocking neurons and preventing them from absorbing serotonin. With more serotonin available in the brain to aid in connecting neurons, people who suffer from mental disorders will often find they have a more balanced mood, more positive emotions, increased energy, and better sleep patterns.
Zoloft is often prescribed as a pill or tablet but can also be found in liquid form, and is often prescribed for use once per day. While Zoloft has a proven record of treating mental health and other disorders, it also holds the potential for abuse.
Side effects sertraline
Zoloft may cause side effects that can be uncomfortable or hazardous to health, though they are not long-term or life-threatening. In rare cases, Zoloft side effects can cause more severe problems, especially in children and young adults. Following reports of suicidal ideation in children taking Zoloft, the FDA has issued a black box warning that states patients should be monitored for worsening or the emergence of suicidal thoughts and behaviors, especially within the first few months of starting medication.
Common side effects from Zoloft include:
- Headache/Dizziness
- Fatigue
- Indigestion/Loss of appetite
- Loss of appetite and libido
- Nausea/vomiting
- Anxiety
- Stomach pain
- Sweating
- Tremors
these side effects may also be indicators of antidepressant abuse or dependence.
Can you overdose on Zoloft?
A Zoloft overdose can occur when too much of the medication is taken in one go, especially when consumed with alcohol or other drugs. Though a Zoloft overdose is rarely fatal if taken on its own, the side effects can be extremely uncomfortable and occasionally can cause more severe damage to the internal organs.
Signs of Zoloft overdose:
- Agitation
- Dizziness
- Fever
- Increased heart rate
- Nausea and vomiting
- Shaking and tremors
- Tiredness
- Delirium
- Hallucinations
- Serotonin syndrome
Serotonin syndrome is a rare condition that can occur when someone abuses SSRIs. The syndrome causes excesses of serotonin to build in the brain which may lead to flu-like symptoms (high body temperature, shivering, fever, muscle tightness), confusion, and life-threatening seizures.
Is Zoloft addictive?
SSRIs like Zoloft and other forms of antidepressants do not cause physical dependence and are not considered addiction forming. While none of traditional hallmarks of addiction are associated with Zoloft, there are some ramifications that may occur from prolonged use. This includes antidepressant discontinuation syndrome.
Zoloft withdrawal: SSRI discontinuation syndrome
Like other forms of SSRI medication, Zoloft has the potential to induce withdrawal symptoms and SSRI Discontinuation Syndrome in those who stop taking it. When someone stops taking SSRI medications after a period of use, the serotonin levels in the brain can decline rapidly. Zoloft has a half-life of around 26 hours, meaning serotonin levels in the brain can decrease within 48 hours. [2] SSRI Discontinuation Syndrome can last between one and two weeks and usually causes rebound symptoms such as depression and anxiety. The severity of withdrawal symptoms will depend on the length of time someone has been taking Zoloft. Other SSRI Discontinuation Syndrome symptoms include:
- Irritability
- Insomnia/Fatigue
- Being distracted
- Dizziness
- Nausea/vomiting
- Nightmares
- Suicidal Ideation
- Tingling sensations in the skin
- Vertigo/Headaches
Most doctors will advise patients using drugs such as Zoloft to taper off of the substance by reducing the dosage or switching to less potent SSRIs.
Related: Lexapro vs Zoloft
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