Vyvanse (lisdexamfetamine) is a stimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD) and binge eating disorder. It is listed in the Controlled Substances Act as a Schedule II substance, due to its potential for addiction and dependence. Vyvanse should always be taken exactly as prescribed.
- Vyvanse is a central nervous system stimulant that is used to treat ADHD and binge eating disorder.
- Vyvanse is a Schedule II controlled substance, as its use can lead to addiction, dependence, abuse, and harm.
- Other types of medication are available to treat ADHD, including non-stimulant medications that are not classified as controlled substances.

Is Vyvanse a controlled substance?
Vyvanse (lisdexamfetamine) is a Schedule II controlled substance under the United States Controlled Substances Act (CSA). [1]
Vyvanse is a central nervous system (CNS) stimulant that is used to treat attention-deficit/hyperactivity disorder (ADHD) in children and adults and binge eating disorder in adults. [2]
Vyvanse contains lisdexamfetamine, a pro-drug of dextroamphetamine. When Vyvanse is ingested, it is converted by the body into dextroamphetamine. [2]
Implications of a Schedule II status
Under the CSA, substances are listed within five categories, ranging from Schedule I substances, which are deemed the most dangerous, to Schedule V. A Schedule II substance is deemed to have: [3]
- High potential for abuse and harm
- Potential for psychological and physical dependence
- Recognized medical use
Vyvanse, like other ADHD medications and CNS stimulants, is highly addictive, even when used as prescribed. The medication is issued with a boxed warning, also known as a black box warning. This is included by the Food and Drug Administration (FDA) on prescription drugs that have the potential to cause serious harm. [2][4]
The boxed warning on Vyvanse includes warnings about its abuse and dependence potential, the safe and lawful distribution of Vyvanse, and the potential for severe or fatal consequences of misuse.
Schedule II substances, such as Vyvanse, can be obtained only with a prescription from a licensed doctor and cannot be bought over the counter. This prescription is written for a set time period and typically expires after 6 months (although this can vary by state). It cannot be refilled and will require a medical review before a new prescription can be written and obtained. [5]
These regulations are in place to help prevent misuse of the medication, such as personal abuse or unlawful distribution.
Comparisons with other ADHD medications
Other ADHD medications classed as CNS stimulants are also Schedule II controlled substances. This includes: [1]
- Methylphenidate (Concerta, Ritalin)
- Amphetamine (Dexedrine, Adderall)
Non-stimulant medications used to treat ADHD are not controlled substances, as they do not share the same potential for abuse and dependence. These medications are typically used as a second-line treatment for ADHD in people who do not respond well to stimulants or cannot take them for other reasons. This includes: [6]
- Atomoxetine (Strattera)
- Viloxazine (Qelbree)
- Guanfacine (Tenex, Intuniv)
- Bupropion (Wellbutrin, Zyban)
Responsible use and risk mitigation
People using Vyvanse should take the medication exactly as prescribed. Never take larger or more frequent doses than prescribed, as this can increase the risk of dependence, adverse effects, and harm. [2] It is also important to meet with the prescribing doctor at regular intervals to review the medication's effectiveness, manage any adverse effects, and alter the dosage if needed.Â
People who are prescribed Vyvanse should not share or sell their medication, even to those with similar symptoms, as this is illegal and dangerous. It should only be used by the person to whom it is prescribed. [2]
Vyvanse should be stored safely, away from children and animals.