Vyvanse and the Controlled Substances Act

Naomi Carr
Dr. David Miles
Written by Naomi Carr on 24 June 2025
Medically reviewed by Dr. David Miles on 24 June 2025

Vyvanse (lisdexamfetamine) is a stimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD) and binge eating disorder. It is listed in the Controlled Substances Act as a Schedule II substance, due to its potential for addiction and dependence. Vyvanse should always be taken exactly as prescribed.

Key takeaways:
  • Vyvanse is a central nervous system stimulant that is used to treat ADHD and binge eating disorder.
  • Vyvanse is a Schedule II controlled substance, as its use can lead to addiction, dependence, abuse, and harm.
  • Other types of medication are available to treat ADHD, including non-stimulant medications that are not classified as controlled substances.
a photo of three Vyvanse pills on cream background with the text Vyvanse controlled substance status

Is Vyvanse a controlled substance?

Vyvanse (lisdexamfetamine) is a Schedule II controlled substance under the United States Controlled Substances Act (CSA).

Vyvanse is a central nervous system (CNS) stimulant that is used to treat attention-deficit/hyperactivity disorder (ADHD) in children and adults and binge eating disorder in adults.

Vyvanse contains lisdexamfetamine, a pro-drug of dextroamphetamine. When Vyvanse is ingested, it is converted by the body into dextroamphetamine.

Implications of a Schedule II status

Under the CSA, substances are listed within five categories, ranging from Schedule I substances, which are deemed the most dangerous, to Schedule V. A Schedule II substance is deemed to have:

  • High potential for abuse and harm
  • Potential for psychological and physical dependence
  • Recognized medical use

Vyvanse, like other ADHD medications and CNS stimulants, is highly addictive, even when used as prescribed. The medication is issued with a boxed warning, also known as a black box warning. This is included by the Food and Drug Administration (FDA) on prescription drugs that have the potential to cause serious harm.

The boxed warning on Vyvanse includes warnings about its abuse and dependence potential, the safe and lawful distribution of Vyvanse, and the potential for severe or fatal consequences of misuse.

Schedule II substances, such as Vyvanse, can be obtained only with a prescription from a licensed doctor and cannot be bought over the counter. This prescription is written for a set time period and typically expires after 6 months (although this can vary by state). It cannot be refilled and will require a medical review before a new prescription can be written and obtained.

These regulations are in place to help prevent misuse of the medication, such as personal abuse or unlawful distribution.

Comparisons with other ADHD medications

Other ADHD medications classed as CNS stimulants are also Schedule II controlled substances. This includes:

  • Methylphenidate (Concerta, Ritalin)
  • Amphetamine (Dexedrine, Adderall)

Non-stimulant medications used to treat ADHD are not controlled substances, as they do not share the same potential for abuse and dependence. These medications are typically used as a second-line treatment for ADHD in people who do not respond well to stimulants or cannot take them for other reasons. This includes:

  • Atomoxetine (Strattera)
  • Viloxazine (Qelbree)
  • Guanfacine (Tenex, Intuniv)
  • Bupropion (Wellbutrin, Zyban)

Responsible use and risk mitigation

People using Vyvanse should take the medication exactly as prescribed. Never take larger or more frequent doses than prescribed, as this can increase the risk of dependence, adverse effects, and harm. It is also important to meet with the prescribing doctor at regular intervals to review the medication's effectiveness, manage any adverse effects, and alter the dosage if needed. 

People who are prescribed Vyvanse should not share or sell their medication, even to those with similar symptoms, as this is illegal and dangerous. It should only be used by the person to whom it is prescribed.

Vyvanse should be stored safely, away from children and animals.

FAQs

Common questions about Vyvanse

Is Vyvanse a narcotic?

Vyvanse is not a narcotic. It is a central nervous system stimulant.

Is Vyvanse an amphetamine?

Will Vyvanse test positive on a drug test?

Drug tests that check for the presence of amphetamines will give a positive result after taking Vyvanse.

What ADHD medication is not a controlled substance?

ADHD medications that are not controlled substances include non-stimulant medications such as atomoxetine (Strattera), viloxazine (Qelbree), guanfacine (Tenex, Intuniv), and bupropion (Wellbutrin). These medications may not be as effective as stimulant medications such as Vyvanse, but they are less likely to cause dependence and addiction.

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Resources:

  1. Drug Enforcement Administration. (2024). Controlled Substances Alphabetical Order. DEA. Retrieved from
  2. Shire LLC. (Revised 2017). Vyvanse (Lisdexamfetamine Dimesylate). FDA. Retrieved from
  3. Drug Enforcement Administration. (n.d). Drug Scheduling. DEA. Retrieved from
  4. Delong, C., Preuss, C.V. (Updated 2023). Box Warning. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing. Retrieved from
  5. What Are The Rules For Controlled Substance Prescription Refills? Drugs.com. Retrieved from
  6. Brancati, G.E., Magnesa, A., Acierno, D., Carli, M., De Rosa, U., Froli, A., Gemignani, S., Ventura, L., Weiss, F., & Perugi, G. (2024). Current Nonstimulant Medications for Adults with Attention-Deficit/Hyperactivity Disorder. Expert Review of Neurotherapeutics, 24(8), 743–759. Retrieved from

Activity History - Last updated: 24 June 2025, Published date:


Reviewer

David is a seasoned Pharmacist, natural medicines expert, medical reviewer, and pastor. Earning his Doctorate from the Medical University of South Carolina, David received clinical training at several major hospital systems and has worked for various pharmacy chains over the years. His focus and passion has always been taking care of his patients by getting accurate information and thorough education to those who need it most. His motto: "Good Information = Good Outcomes".

Activity History - Medically Reviewed on 23 June 2025 and last checked on 24 June 2025

Medically reviewed by
Dr. David Miles

Dr. David Miles

PharmD

Reviewer

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