Adderall Crash: Symptoms, Timeline, and Management

Dr. Nicolette Natale
Dr. David Miles
Written by Dr. Nicolette Natale on 26 May 2025
Medically reviewed by Dr. David Miles on 28 May 2025

Adderall, also known as dextroamphetamine/amphetamine salts, is a commonly prescribed stimulant for attention-deficit/hyperactivity disorder (ADHD). It has been shown to improve focus, attention, and energy levels significantly.

Unfortunately, once the effects of the medication wear off, many users experience what’s known as an Adderall crash—a sudden drop in mood, energy, and cognitive function. Because of the stimulating effects of Adderall, when the body adjusts to suddenly stopping the drug, it can result in opposing side effects.

Below, we’ll discuss the symptoms, timeline, and management of an Adderall crash to help individuals taking this medication appropriately identify and cope with these symptoms if they stop taking the drug.

Key takeaways:
  • An Adderall crash or adderall comedown refers to the period after the drug’s effects wear off, characterized by fatigue, irritability, and difficulty concentrating.
  • Crashes typically begin within hours after the last dose and may last several hours to a few days, depending on dose, frequency, and individual metabolism.
  • Strategies like staying hydrated, never taking more of the medication than prescribed, eating balanced meals, getting rest, and seeking medical guidance can help reduce the risk of crash symptoms and prevent long-term complications.
a cut-out drawing of a head with low battery levels due to Adderall crash

Understanding the Adderall crash

An Adderall crash is a set of physical and psychological symptoms that occur as the effects of the stimulant medication wear off. It is essentially the body adjusting to being without the drug and is also referred to as an Adderall comedown.

This crash is typically more immediate and short-term than Adderall withdrawal, which refers to longer-lasting symptoms following discontinuation of the drug after a prolonged period of use.

  • Adderall crash: Begins within hours after the last dose; symptoms are short-lived and directly related to the drug’s waning effects.
  • Adderall withdrawal: May occur after chronic use and includes more persistent symptoms like depression, sleep disturbances, and cravings, which can last days to weeks.

Adderall is considered a controlled substance and a Schedule II drug, which means it has a relatively high risk for dependency or addiction. While both experiences are tied to stimulant use, withdrawal is more closely associated with dependency and long-term neurochemical changes in the brain.

Symptoms of an Adderall crash

Symptoms of an Adderall crash can vary based on individual health, dosage, and frequency of use, but common experiences include:

  • Extreme fatigue or exhaustion.
  • Depressed mood or sadness.
  • Irritability or agitation.
  • Difficulty focusing or mental fog.
  • Increased appetite.
  • Sleep disturbances or oversleeping.
  • Anxiety or restlessness.

These effects are due to the sudden drop in dopamine and norepinephrine levels after Adderall use, which disrupts the brain’s natural balance.  

Timeline and duration

Crash symptoms usually begin within 6–12 hours after the last dose of Adderall, especially if the medication was short-acting. Symptoms may be delayed for extended-release formulations, but still occur once the drug clears the system. The average Adderall crash lasts between 1 to 3 days, although for some, symptoms may linger longer, especially if use has been chronic or at high doses.

Several factors can affect the intensity and length of a crash:

  • Dosage and frequency: Higher or repeated doses can lead to more intense crashes.
  • Formulation: Immediate-release Adderall causes quicker crashes, while extended-release may have a slower decline and a less severe crash.
  • Sleep and nutrition: Poor sleep or malnutrition can worsen crash symptoms.
  • Mental health status: Individuals with underlying anxiety or depression may experience more pronounced emotional symptoms.

Coping strategies and remedies

Managing an Adderall crash involves supporting the body and mind during the recovery period. Helpful strategies include:

  • Hydration and nutrition: Eat balanced meals rich in protein and complex carbs to stabilize blood sugar and mood.
  • Rest and sleep: Prioritize restorative sleep to help the brain recalibrate.
  • Gentle physical activity: Light exercise like walking or yoga can help relieve tension and boost mood.
  • Mindfulness techniques: Practices like meditation or deep breathing may reduce anxiety and irritability.
  • Avoid caffeine and alcohol: These substances can exacerbate mood swings and interfere with recovery.

Over-the-counter options like melatonin may help with sleep issues, but consult with a medical provider before starting any new supplement.

Preventing Adderall crashes

The best way to prevent a crash is to take Adderall exactly as prescribed and under medical supervision. Other tips for prevention include:

  • Avoid skipping meals while medicated.
  • Stick to a consistent sleep schedule.
  • Only take the prescribed amount of the medication. Never take more than prescribed, as this can increase the risk for an Adderall crash, more severe side effects, and dependency.
  • Don’t mix Adderall with alcohol or other drugs, which can intensify crashes and lead to dangerous interactions.
  • Taper use gradually if you and your provider decide to discontinue the medication, to avoid withdrawal symptoms.

If you’re using Adderall without a prescription, the risk of crashing increases significantly, especially with inconsistent dosing or combining with other substances.

When to seek professional help

While occasional mild crashes are common, specific symptoms may indicate a more serious issue:

  • Severe depression or suicidal thoughts
  • Panic attacks or paranoia
  • Inability to function in daily life
  • Physical symptoms like chest pain or hallucinations

These may be signs of Adderall misuse, dependency, or an underlying mental health condition. If you experience any of the above symptoms, seeking professional help or emergency medical attention is essential.

Medical providers can help you taper off of Adderall safely or explore non-stimulant alternatives for ADHD treatment, such as atomoxetine, guanfacine, or bupropion. These medications work differently from Adderall for treating symptoms of ADHD, and may work better for some individuals who are sensitive to the stimulant effects of Adderall.  

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Resources:

  1. Shoar NS, Marwaha R, Molla M. Dextroamphetamine-Amphetamine. NIHgov. Published online May 23, 2023.
  2. Berman SM, Kuczenski R, McCracken JT, London ED. Potential Adverse Effects of Amphetamine Treatment on Brain and behavior: a Review. Molecular Psychiatry. 2008;14(2):123-142.
  3. Pliszka S. Practice Parameter for the Assessment and Treatment of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder. Journal of the American Academy of Child & Adolescent Psychiatry. 2017;46(7):894-921.
  4. Lamberti M, Italiano D, Guerriero L, et al. Evaluation of Acute Cardiovascular Effects of Immediate-release Methylphenidate In children and Adolescents with Attention-Deficit Hyperactivity Disorder. Neuropsychiatric Disease and Treatment. Published online May 2015:1169.
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Activity History - Last updated: 28 May 2025, Published date:


Reviewer

David is a seasoned Pharmacist, natural medicines expert, medical reviewer, and pastor. Earning his Doctorate from the Medical University of South Carolina, David received clinical training at several major hospital systems and has worked for various pharmacy chains over the years. His focus and passion has always been taking care of his patients by getting accurate information and thorough education to those who need it most. His motto: "Good Information = Good Outcomes".

Activity History - Medically Reviewed on 25 May 2025 and last checked on 28 May 2025

Medically reviewed by
Dr. David Miles

Dr. David Miles

PharmD

Reviewer

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