Codeine and Tylenol

Edmund Murphy
Dr. Jennie Stanford
Written by Edmund Murphy on 07 January 2022
Medically reviewed by Dr. Jennie Stanford on 25 November 2024

Codeine can be a primary ingredient of certain prescribed versions of Tylenol, alongside acetaminophen. The quantities of codeine in Tylenol vary depending on the strength. Over-the-counter versions of Tylenol (acetaminophen) do not contain codeine.

Key takeaways:
  • Due to health risks associated with taking high amounts of acetaminophen, the FDA enforced requirements that codeine-containing Tylenol products contain no more than 300mg of acetaminophen per dose.
Box of Tylenol Extra Strength Rapid Release Gels, 24 Gelcaps, 500 mg.

How much codeine is in Tylenol?

The combination of acetaminophen and codeine, sold under some brand names of Tylenol, has been a popular form of pain relief in the United States for many years, though Tylenol is not codeine in and of itself. Acetaminophen (Tylenol) is commonly sold over the counter in forms without codeine, and it is an effective pain reliever for mild-to-moderate pain.

Due to health risks associated with intaking high amounts of acetaminophen, the FDA enforced requirements that Tylenol products contain no more than 300mg of acetaminophen per dose. In addition to Tylenol (acetaminophen) without codeine, there are four variations of Tylenol that do contain codeine, each with varying strengths of codeine, labeled by number.

The doses in each form of Tylenol are below:

Tylenol typeDose of Codeine and Acetaminophen
Tylenol No. 1300mg Acetaminophen and 7.5mg Codeine
Tylenol No. 2300mg Acetaminophen and 15mg Codeine
Tylenol No. 3300mg Acetaminophen and 30mg Codeine
Tylenol No. 4300mg Acetaminophen and 60mg Codeine
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Resources:

  1. Drugs@FDA: FDA-Approved Drugs. (n.d.). Retrieved November 16, 2024, from

Activity History - Last updated: 25 November 2024, Published date:


Reviewer

Dr. Jennie Stanford

MD, FAAFP, DipABOM

Jennie Stanford, MD, FAAFP, DipABOM is a dual board-certified physician in both family medicine and obesity medicine. She has a wide range of clinical experiences, ranging from years of traditional clinic practice to hospitalist care to performing peer quality review to ensure optimal patient care.

Activity History - Medically Reviewed on 15 December 2022 and last checked on 25 November 2024

Medically reviewed by
Dr. Jennie Stanford

Dr. Jennie Stanford

MD, FAAFP, DipABOM

Reviewer

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