Valium (Diazepam) in your System: Duration and Detection

Naomi Carr
Dr. Jennie Stanford
Written by Naomi Carr on 02 May 2025
Medically reviewed by Dr. Jennie Stanford on 12 May 2025

Valium (diazepam) is a benzodiazepine used to treat anxiety disorders, symptoms of alcohol withdrawal, muscle spasms, and seizure disorders. Valium can be detected in the body for many days after use. It can be helpful to understand the times required to metabolize and eliminate Valium, as this can help ensure safe medication use and manage withdrawal.

Valium can be detected with the use of blood, saliva, urine, and hair tests, which differ in their detection windows. Various factors can impact the elimination time of Valium, including frequency and amount of use, age and weight, and liver function.

Type of testPeak detection timeDetection window
UrineWithin 24 hours after useUp to 15 days
BloodWithin 2 hours of useUp to 10 days
SalivaWithin minutes of useUp to 7 days
HairDays after useUp to 90 days
Key takeaways:
  • Valium (diazepam) is a benzodiazepine used to treat anxiety disorders, alcohol withdrawal symptoms, muscle spasms, and seizure disorders.
  • Valium has a half-life of 24–48 hours and is entirely eliminated from the body in up to 10 days.
  • Valium can be detected with the use of urine, blood, saliva, or hair tests.
a photo of Valium pills coming out of a pill bottle arranged in a question mark

Understanding Valium's duration in the body

Valium has a half-life of 24–48 hours, and it takes around five half-lives for it to be entirely eliminated from the body, which is 5–10 days.

Valium (diazepam) is a benzodiazepine medication, and it is approved to treat anxiety disorders, acute anxiety symptoms, and alcohol withdrawal symptoms. It may also be used alongside other medications to treat muscle spasms and seizure disorders.

Valium is available as a tablet in 2 mg, 5 mg, and 10 mg strengths. Depending on the condition and individual factors, a typical daily dose of Valium is 2 mg to 10 mg, taken up to 4 times per day.

Valium is metabolized by the liver and eliminated by the kidneys. This means that urine samples can be an effective means to test for the detection of Valium. The half-life of Valium is 24–48 hours, although this can be longer in older adults, newborns, and those with impaired liver functioning.

How long do Valium effects last?

After taking Valium, the effects are often felt within 30-90 minutes, although this may take longer if it is administered with a large meal. Valium causes sedating, calming, muscle-relaxant, and anticonvulsant effects. These effects can continue for around 12 hours, although this varies, and some people may require more frequent doses.

Valium detection windows in drug tests

Tests that can be used to detect Valium include urine, saliva, blood, and hair tests. These tests might be used to check for the presence of Valium in the workplace, at the roadside, in drug-related crimes, or to help manage withdrawal. Urine tests are the most commonly used, as they can be administered several days after use and are often an accurate method of detection.

Urine tests

Valium can be detected in urine within 24 hours of use and for up to 15 days after use.

Blood tests

Blood tests can detect Valium within 2 hours of use and for up to 10 days after use.

Saliva tests

Valium can be detected in saliva within minutes of use and for up to 7 days after use.

Hair tests

Hair tests are not often used, as they may not always be accurate, although they can detect Valium after repeated use.

Factors influencing Valium's duration in the system

The elimination and detection times of Valium can vary depending on several factors, including:

  • Amount and frequency of use
  • Age and weight
  • Liver and kidney functioning
  • Other substance use
  • Health issues

Implications of prolonged presence

Prolonged use of Valium can increase the likelihood of dependence, tolerance, and addiction. This can mean an increased chance of withdrawal symptoms, a need to take higher doses to achieve the desired effects, and addictive behaviors leading to negative consequences within daily functioning and overall mental and physical health.

Prolonged and heavy use of Valium can also increase the elimination time of Valium, meaning that it can be detected in tests for longer. This can impact withdrawal and detox treatments for Valium dependence, potentially increasing the severity and duration of withdrawal symptoms. It may also have implications for professional functioning, driving ability, and safe dosing for medical procedures.

Valium withdrawal and timeline

Benzodiazepines, including Valium (diazepam), are likely to cause dependence with prolonged use. This can lead to withdrawal symptoms when stopping.

Withdrawal symptoms of Valium can include cramps, headache, anxiety, confusion, irritability, and insomnia. Withdrawal symptoms can be more severe if Valium has been taken in large doses or for a prolonged period of over four weeks.

It is advised to gradually reduce the dosage when stopping Valium treatment, rather than stopping abruptly, as this can reduce the risk of withdrawal symptoms. A safe tapering schedule will differ from person to person, and people with a more severe dependence may require a slower taper.

Generally, doses will be reduced by 5–25% every 1–4 weeks, which is typically monitored by the prescribing doctor to manage and treat any withdrawal symptoms.

FAQs

Common questions about Valium duration in the body

Can other medications affect how long Valium stays in your system?

Some medications may impact the metabolization or elimination of Valium, affecting how long it remains in the system. These can include fluoxetine, some antibiotics, and protease inhibitors.

How fast does Valium kick in?

The effects of Valium can be felt after 30–90 minutes.

What can give a false positive for Valium?

Some medications can cause a false positive test result for Valium, meaning that a test indicates the presence of Valium when it has not been used. Medications that can cause a false positive result include efavirenz, oxaprozin, and sertraline. This can occur due to traces of benzodiazepines in the medication or cross-reactions within the test.

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Resources:

  1. Calcaterra, N.E., & Barrow, J.C. (2014). Classics in Chemical Neuroscience: Diazepam (Valium). ACS Chemical Neuroscience, 5(4), 253–260. Retrieved from
  2. Genentech USA, Inc. (Revised 2016). Valium (Diazepam) Label. US Food and Drug Administration. Retrieved April 8, 2025 from
  3. Mandelli, M., Tognoni, G., & Garattini, S. (1978). Clinical Pharmacokinetics of Diazepam. Clinical Pharmacokinetics, 3(1), 72–91.
  4. Wang, L.L., Ren, X.X., He, Y., Cui, G.F., Liu, J.J., Jia, J., Cao, J., Liu, Y., Cong, B., Wei, Z.W., & Yun, K.M. (2022). Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs in R&D, 22(1), 43–50.
  5. Nordal, K., Øiestad, E.L., Enger, A., Christophersen, A.S., & Vindenes, V. (2015). Detection Times of Diazepam, Clonazepam, and Alprazolam in Oral Fluid Collected From Patients Admitted to Detoxification, After High and Repeated Drug Intake. Therapeutic Drug Monitoring, 37(4), 451–460.
  6. Laloup, M., Fernandez, M.D.M., Wood, M., Maes, V., De Boeck, G., Vanbeckevoort, Y., & Samyn, N. (2007). Detection of Diazepam in Urine, Hair and Preserved Oral Fluid Samples with LC-MS-MS after Single and Repeated Administration of Myolastan and Valium. Analytical and Bioanalytical Chemistry, 388(7), 1545–1556.
  7. Sarkar, S., Choudhury, S., Islam, N., Chowdhury, M. S. J. H., Chowdhury, M. T. I., Baker, M. R., Baker, S. N., & Kumar, H. (2020). Effects of Diazepam on Reaction Times to Stop and Go. Frontiers in human neuroscience, 14, 567177.
  8. Ogbonna, C.I., & Lembke, A. (2017). Tapering Patients Off of Benzodiazepines. American Family Physician, 96(9), 606–610.
  9. Możdżeń, K., Kaleta, K., Murawska, A., Pośpiech, J., Panek, P., Lorkowska-Zawicka, B., & Bujak-Giżycka, B. (2023). Guilty or Not Guilty? - False Positive Results of Common Medicines in Drug Tests: Review and Practical Guide. Folia Medica Cracoviensia, 63(2), 107–134.

Activity History - Last updated: 12 May 2025, Published date:


Reviewer

Dr. Jennie Stanford

MD, FAAFP, DipABOM

Jennie Stanford, MD, FAAFP, DipABOM is a dual board-certified physician in both family medicine and obesity medicine. She has a wide range of clinical experiences, ranging from years of traditional clinic practice to hospitalist care to performing peer quality review to ensure optimal patient care.

Activity History - Medically Reviewed on 01 April 2025 and last checked on 12 May 2025

Medically reviewed by
Dr. Jennie Stanford

Dr. Jennie Stanford

MD, FAAFP, DipABOM

Reviewer

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