Triazolam (Halcion) Side Effects & Safety Guide

Naomi Carr
Dr. David Miles
Written by Naomi Carr on 26 June 2025
Medically reviewed by Dr. David Miles on 27 June 2025

Triazolam (Halcion) is a benzodiazepine medication used primarily for the short-term treatment of insomnia. Triazolam is a potent and controlled medication with the potential for side effects and dependency. As such, it should be taken exactly as prescribed and should not be used in larger doses or for longer durations than recommended.

Key takeaways:
  • Triazolam (Halcion) is a benzodiazepine medication used to treat insomnia.
  • Halcion can cause side effects and has the potential for abuse and dependency. It is a Schedule IV controlled substance.
  • Because of its risks, Halcion should only be used for short-term treatment.
a photo of a hand holding blue Halcion pills and the text Triazolam (Halcion) side effects beside it

Common side effects of Halcion (triazolam)

Common side effects of Halcion (triazolam) include:

  • Sedation
  • Drowsiness
  • Dizziness
  • Light-headedness
  • Impaired memory
  • Impaired coordination
  • Nausea or vomiting

Severe side effects

Serious side effects of Halcion can be less common but may occur. If any of the following side effects occur or worsen, consult the prescribing doctor, as medical attention or treatment changes may be necessary:

  • Extreme changes in heart rate
  • Severe confusion or memory loss
  • Depression
  • Suicidal ideation
  • Jaundice
  • Incontinence
  • Psychotic symptoms such as hallucinations, delusions, or paranoia
  • Mania
  • Aggressiveness
  • Agitation and restlessness
  • Falls
  • Chest pain or trouble breathing

Long-term risks and mental health impacts

Long-term use of Halcion can result in the development of tolerance, dependence, and addiction. Because of this, Halcion should only be used for short-term management of symptoms. It is recommended for only 7-10 days, or if treatment of longer than 2-3 weeks is necessary, regular monitoring and reevaluation are required.

Halcion may cause changes to mental state and behavior, including mania, low mood, anxiety, psychotic symptoms, and aggression, which should be reported to a doctor.

Interactions with other substances

Using Halcion with other medications or substances can cause an increased risk of harm. In particular, the concomitant use of opioids and Halcion can increase the risk of oversedation, respiratory depression, coma, and death.

Similarly, it can be dangerous to use Halcion with other substances that act as central nervous system depressants, such as some anticonvulsants, antihistamines, antipsychotics, antidepressants, and alcohol.

Dependency and withdrawal

All benzodiazepines are Schedule IV controlled substances due to their potential for dependency and addiction. Halcion is a potent and short-acting benzodiazepine with this same potential.

Physical dependence can develop within two weeks of Halcion use, and can be more common with prolonged use or high doses. This can lead to withdrawal symptoms when treatment is stopped, which can be life-threatening.

Halcion withdrawal symptoms can include rebound insomnia, meaning that sleep disturbances are temporarily worse than prior to treatment. Other withdrawal symptoms can include stomach cramps, nausea and vomiting, sweating, shaking, and in some cases, seizures.

Tapering safely from triazolam

To help reduce the impact of withdrawal symptoms, Halcion use should not be abruptly stopped. It is recommended to make gradual dose reductions when ending treatment, known as tapering. This is particularly important for people who have been using Halcion for more than a few weeks and in high doses.

Managing side effects

Halcion should be taken at night, as it can help with sleep and may cause daytime drowsiness if taken earlier in the day.

Drowsiness and light-headedness can be common with Halcion use. It may be necessary to avoid driving while using Halcion treatment to prevent accidents. Additionally, falls may be more likely, so caution should be taken during activity.

Halcion treatment is often short, and side effects are often alleviated with the discontinuation of the medication. However, serious side effects, such as breathing difficulties, extreme changes in mood/behavior, or severe cognitive impairments, may need to be managed by a medical professional. It might be necessary to stop Halcion treatment if serious side effects occur.

Overdose symptoms and emergency response

Halcion use can lead to overdose, particularly when using doses higher than the recommended amount. Signs of Halcion overdose can include:

  • Weakness
  • Confusion
  • Slurred speech
  • Impaired coordination
  • Loss of consciousness
  • Difficulty breathing
  • Seizures

If Halcion overdose is suspected, call 911 immediately, as medical attention may be necessary. Treatment can include the administration of flumazenil, a benzodiazepine antagonist, stomach pumping, and airway and breathing management.

Alternatives to triazolam for insomnia

Other medications can be used to treat insomnia or other sleep disturbances, including:

Additionally, as insomnia is often related to other causes, psychological support can help to improve sleep, such as cognitive behavioral therapy for insomnia (CBT-I). CBT-I can help with associated issues such as anxiety, stress, worrying about sleep, sleep hygiene habits, and improving the sleep-wake cycle.

Implementing healthy sleep habits can also be beneficial to improve insomnia symptoms, including:

  • Avoiding caffeine, nicotine, and alcohol
  • Exercising during the day
  • Engaging in relaxing activities before bed, such as meditation, bathing, or reading
  • Ensuring the bedroom is dark and quiet
  • Learning about and implementing stress-management techniques

Halcion vs. Ambien

Ambien (zolpidem) is also used as a treatment for insomnia. Halcion is a benzodiazepine, while Ambien is a non-benzodiazepine hypnotic, classed as an imidazopyridine.

Similarities include:

  • Both are Schedule IV controlled substances
  • Both are used to treat insomnia
  • Both are short-acting
  • Both have some potential for abuse and dependence
  • Both create sedating and calming effects
  • Side effects and drug interactions are similar
  • Both are recommended only for short-term use

FAQs

Common questions about triazolam side effects

Can triazolam be dangerous?

Yes, triazolam can be dangerous if misused, such as by using higher or more frequent doses than prescribed. It can lead to addiction, dependence, abuse, and overdose.

What does triazolam do to the brain?

Triazolam is a central nervous system (CNS) depressant. It sedates the brain and nervous system, which creates its benefits in sleep disorders. This also contributes to its cognitive effects, such as impaired memory and concentration. Additionally, it increases the risk of mental effects such as depression, anxiety, and addiction.

Can triazolam cause memory loss?

Memory loss can occur with triazolam use.

Why was triazolam banned?

Triazolam (Halcion) has been banned in the United Kingdom (UK) since the early 1990s, due to risks associated with the use of the medication. It is still available in the US.

Can triazolam cause addiction?

Yes, triazolam use can lead to addiction. This risk may be increased if the medication is used for longer or in higher doses than recommended.

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Resources:

  1. Pharmacia & Upjohn Co. (Revised 2016). Halcion (Triazolam) Tablets. FDA. Retrieved from
  2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (2012). Triazolam. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved from
  3. Triazolam. (2024). Drugs.com. Retrieved from
  4. National Institutes of Health. (Updated 2022). Insomnia Treatment. NIH. Retrieved from
  5. Sanofi-Aventis U.S. LLC. (2008). Ambien Label. FDA. Retrieved from
  6. Rosenberg, J., & Ahlstrøm, F. (1994). Randomized, Double Blind Trial of Zolpidem 10 mg Versus Triazolam 0.25 mg for Treatment of Insomnia in General Practice. Scandinavian Journal of Primary Health Care12(2), 88–92. Retrieved from
  7. Gabe, J. (1997). La controverse sur l'Halcion en Grande-Bretagne: une étude sociologique [The Controversy about Halcion in Great Britain: A Sociological Study]. Sante Mentale au Quebec22(1), 301–316. Retrieved from

Activity History - Last updated: 27 June 2025, Published date:


Reviewer

David is a seasoned Pharmacist, natural medicines expert, medical reviewer, and pastor. Earning his Doctorate from the Medical University of South Carolina, David received clinical training at several major hospital systems and has worked for various pharmacy chains over the years. His focus and passion has always been taking care of his patients by getting accurate information and thorough education to those who need it most. His motto: "Good Information = Good Outcomes".

Activity History - Medically Reviewed on 25 June 2025 and last checked on 27 June 2025

Medically reviewed by
Dr. David Miles

Dr. David Miles

PharmD

Reviewer

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