Cyclobenzaprine, better known by the brand names Flexeril and Amrix, is not currently regulated by the DEA under the Controlled Substance Act, though this is widely contested.

Flexeril controlled substance status

As confirmed in a report from March 2020 by the Drug Enforcement Administration (DEA), Cyclobenzaprine, also known as Flexeril and Amrix, is still not scheduled under the Controlled Substances Act (CSA).[1]

Get help during covid-19

Get help during Covid-19

At Recovered, we recognize the impact COVID-19 has had and the continued challenges it poses to getting advice and treatment for substance use disorders. SAMHSA has a wealth of information and resources to assist providers, individuals, communities, and states during this difficult time and is ready to help in any way possible.

Speak to SAMSHA


Cyclobenzaprine interacts with the central nervous system (CNS) as a muscle relaxant. Flexeril and Amrix are often prescribed to treat muscle pain, sprains, tenderness, and musculoskeletal pain.[1] While the drug is safe to use on its own, the relaxing properties of the drug increase the risk of it being misused. 

The DEAs research outlines growing reports of people abusing Flexeril alongside other CNS depressants, such as benzodiazepines and alcohol, in order to enhance the euphoric effects of the substances.[1]

Research from the American Association of Poison Control Centers and the Drug Abuse Warning Network Emergency Department (DAWN ED) indicates concerning statistics surrounding Flexeril abuse:

  • In 2016 and 2017, there were over 20,000 reported cases of cyclobenzaprine abuse, with over 150 medical incidents and 5 deaths across both years.
  • There was a 101% increase in hospital room visits associated with cyclobenzaprine abuse, from around 6000 to over 12000, between 2004 and 2010.[1]

Flexeril addiction

While Flexeril is not currently regulated under the CSA, there is strong evidence to indicate that the drug holds the potential for abuse, dependence, and addiction. 

Abusing prescription medication like Flexeril can greatly increase the likelihood of developing an addiction. If you or someone you care about is at risk of becoming addicted to Flexeril, or if a drug dependence has already formed, then contact an addiction rehab center today.